Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Tetrabuthylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrabuthylammonium SCHEMBL11246970 | 0.98 | SLC22A1 (0.55) | SLC22A1TSHRALOX12LMNAACHE | |
| Tetrabuthylammonium SCHEMBL1724097 | 0.96 | SLC22A1 (0.52) | SLC22A1TSHRALOX12LMNAACHE | |
| Tetrabuthylammonium SCHEMBL15453961 | 0.96 | SLC22A1 (0.52) | SLC22A1TSHRALOX12LMNAACHE | |
| Toluene SCHEMBL5210472 | 0.91 | SLC22A1 (0.56) | SLC22A1TSHRALOX12LMNAACHE | |
| Toluene SCHEMBL6950304 | 0.89 | SMN1; SMN2 (0.58) | SLC22A1TSHRALOX12LMNASLC22A2 | |
| Toluene SCHEMBL29111168 | 0.89 | SLC22A1 (0.54) | SLC22A1TSHRALOX12SLC22A2DNM1 | |
| Tetrabuthylammonium SCHEMBL5571715 | 0.87 | KCNH2 (0.45) | SLC22A1TSHRALOX12LMNAACHE | |
| Tetrabuthylammonium SCHEMBL8027007 | 0.86 | SLC22A1 (0.63) | SLC22A1TSHRALOX12ACHESLC22A2 | |
| Dodecane SCHEMBL28292270 | 0.86 | LMNA (0.58) | TSHRALOX12LMNAACHEDNM1 | |
| Heptane SCHEMBL27684378 | 0.86 | LMNA (0.58) | TSHRALOX12LMNAACHEDNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106981572-B | It is a kind of to prepare the modified CeO in surface2The method and product of nano material and application | 华中科技大学 | 2019-03-08 | — | — | CN | disclosed |