Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547950 | 0.88 | KCNH2 (0.42) | KCNH2LNPEPLMNAKDM4ECYP3A4 | |
| SCHEMBL18799858 | 0.83 | LMNA (0.40) | KCNH2LNPEPLMNAKDM4ECYP3A4 | |
| SCHEMBL27345654 | 0.81 | KCNH2 (0.42) | KCNH2LNPEPLMNAKDM4ECYP3A4 | |
| SCHEMBL1328611 | 0.77 | LNPEP (0.48) | KCNH2LNPEPLMNAKDM4ECYP3A4 | |
| SCHEMBL31280277 | 0.75 | NOS3 (0.50) | KCNH2LNPEPLMNAKDM4ECYP3A4 | |
| SCHEMBL921653 | 0.75 | KDM4E (0.47) | KCNH2LMNAKDM4ECYP3A4TSHR | |
| SCHEMBL1030077 | 0.75 | KDM4E (0.47) | KCNH2LMNAKDM4ECYP3A4TSHR | |
| SCHEMBL2550616 | 0.75 | NOS3 (0.50) | KCNH2LNPEPLMNAKDM4ECYP3A4 | |
| SCHEMBL29058198 | 0.75 | KCNH2 (0.50) | KCNH2LNPEPLMNAKDM4ECYP3A4 | |
| SCHEMBL2553622 | 0.75 | CYP3A4 (0.46) | KCNH2LNPEPLMNAKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109415358-A | 6-aminopyridin-3-ylthiazoles as ROR gamma t modulators | 詹森药业有限公司 | 2019-03-01 | — | — | CN | disclosed |