Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetohydroxamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280150 | 0.88 | MAPT (0.54) | MEN1KMT2AALOX15MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL27286730 | 0.86 | MAPT (0.52) | MEN1KMT2AALOX15MAPTMAPK1 | |
| Butyrophenone SCHEMBL28870598 | 0.80 | L3MBTL1 (0.57) | MEN1KMT2AALOX15MAPTMAPK1 | |
| SCHEMBL5682430 | 0.77 | MEN1 (0.57) | MEN1KMT2AALOX15MAPTMAPK1 | |
| SCHEMBL26687976 | 0.77 | MAPK1 (0.57) | MEN1KMT2AMAPTMAPK1HPGD | |
| SCHEMBL8752484 | 0.77 | ALDH1A1 (0.60) | MEN1KMT2AMAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL8752521 | 0.75 | SMN1; SMN2 (0.57) | MEN1KMT2AMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL28113087 | 0.75 | ALDH1A1 (0.50) | MEN1KMT2AMAPTHPGDSMN1; SMN2 | |
| Acetoacetic Acid SCHEMBL27810058 | 0.75 | HAO1 (0.45) | MEN1KMT2AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL8779987 | 0.73 | ERCC5 (0.61) | MEN1KMT2AMAPTMAPK1ERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109535140-A | A method of double indoles substituted-dihydro pyrrolones derivatives are constructed based on oxime ester and indoles | 常州大学 | 2019-03-29 | — | — | CN | disclosed |