Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.61 |
| ▸ | FEN1 | P39748 | 2/20 | 0.61 |
| ▸ | KMO | O15229 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280150 | 0.84 | MAPT (0.54) | ERCC5FEN1ALOX5POLBMAPK1 | |
| SCHEMBL11756446 | 0.83 | TP53 (0.56) | KMONPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL27286730 | 0.82 | MAPT (0.52) | ERCC5FEN1ALOX5POLBMAPK1 | |
| SCHEMBL9035708 | 0.79 | CES2 (0.55) | POLBHDAC1HDAC6MEN1HTT | |
| SCHEMBL4869301 | 0.79 | CA12 (0.50) | KMOALDH1A1 | |
| SCHEMBL339923 | 0.78 | ERCC5 (0.58) | ERCC5FEN1ALOX5ALDH1A1KMT2A | |
| SCHEMBL28415551 | 0.78 | CES2 (0.66) | KMOPRSS1PRSS2PRSS3MAPK1 | |
| SCHEMBL8980284 | 0.78 | PBRM1 (0.49) | KMOPRSS1PRSS2PRSS3POLB | |
| SCHEMBL5619554 | 0.78 | PARP1 (0.50) | ALOX5ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL1277041 | 0.78 | PARP1 (0.50) | HDAC8POLBHDAC6MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783486-A1 | NOVEL PROSTAGLANDIN SYNTHASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-07-16 | — | — | EP | disclosed |