SCHEMBL28874178

SCHEMBL28874178

Cc1csc(-c2ccc(NC(=O)NC3CCCC3O)cc2)n1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.41
POLB P06746 1/20 0.41
CNR1 P21554 1/20 0.40
NPC1 O15118 6/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
EPHX1 P07099 1/20 0.39
NTMT1 Q9BV86 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38
PPARA Q07869 1/20 0.38
NAMPT P43490 2/20 0.38
MAP4K1 Q92918 1/20 0.37
CDK5 Q00535 1/20 0.37
CDK5R1 Q15078 1/20 0.37
CCR3 P51677 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13680523 0.77 RAB9A (0.51) RAB9APOLBNPC1SMN1; SMN2MEN1
SCHEMBL13680522 0.76 RAB9A (0.55) RAB9APOLBNPC1SMN1; SMN2MEN1
SCHEMBL13680537 0.73 KIF11 (0.54) RAB9APOLBNPC1SMN1; SMN2MEN1
SCHEMBL13680489 0.72 SMN1; SMN2 (0.47) RAB9APOLBNPC1SMN1; SMN2MEN1
SCHEMBL13680476 0.71 TSHR (0.47) RAB9APOLBNPC1SMN1; SMN2MEN1
SCHEMBL31668983 0.70 CHRM1 (0.46)
SCHEMBL21873434 0.70 CHRM1 (0.46)
SCHEMBL21873623 0.69 CHRM1 (0.48)
SCHEMBL30428222 0.69 CHRM1 (0.48)
SCHEMBL23657507 0.68 NPC1 (0.56) RAB9APOLBNPC1SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115286592-A GLUT1 inhibitor, virtual screening method and application 武汉工程大学 2022-11-04 CN claimed
CN-115286592-A GLUT1 inhibitor, virtual screening method and application 武汉工程大学 2022-11-04 CN disclosed