Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020298 | 0.84 | PTGS2 (0.55) | PTGS2NPSR1SMN1; SMN2GAAKDM4E | |
| Hydrogen Sulfide SCHEMBL8030072 | 0.83 | PTGS2 (0.54) | PTGS2SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL11356431 | 0.81 | L3MBTL1 (0.73) | NPSR1SMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL20984200 | 0.81 | PTGS2 (0.64) | PTGS2NPSR1SMN1; SMN2GAAKDM4E | |
| SCHEMBL425146 | 0.79 | PTGS2 (0.62) | PTGS2NPSR1SMN1; SMN2GAAKDM4E | |
| SCHEMBL2831390 | 0.79 | PTGS2 (0.67) | PTGS2NPSR1SMN1; SMN2GAAKDM4E | |
| SCHEMBL4365909 | 0.79 | PTGS2 (0.54) | PTGS2NPSR1SMN1; SMN2GAAKDM4E | |
| SCHEMBL4028705 | 0.78 | PTGS2 (0.60) | PTGS2NPSR1SMN1; SMN2GAAKDM4E | |
| SCHEMBL6637261 | 0.77 | GAA (0.62) | PTGS2SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL9771265 | 0.76 | L3MBTL1 (0.59) | SMN1; SMN2KDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197696-A1 | PESTICIDAL HETEROCYCLIC DIHALOALLYL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-05 | — | — | US | disclosed |
| US-7723362-B2 | Pesticidal heterocyclic dihaloallyl compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20070299064-A1 | Pesticidal Heterocyclic Dihaloallyl Compounds | SYNGENTA CROP PROTECTION, INC. | 2007-12-27 | — | — | US | disclosed |
| EP-1706392-A2 | PESTICIDAL HETEROCYCLIC DIHALOALLYL COMPOUNDS | Syngenta Participations AG (CH) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005068445-A2 | PESTICIDAL HETEROCYCLIC DIHALOALLYL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299064-A1 | Pesticidal Heterocyclic Dihaloallyl Compounds | DDT, CYP8B1, EPHX2 | PTGS2 603/4885NPSR1 1225/4885SMN1; SMN2 4722/4885 |
| US-20100197696-A1 | PESTICIDAL HETEROCYCLIC DIHALOALLYL COMPOUNDS | DDT, CYP8B1, EPHX2 | PTGS2 603/4885NPSR1 1225/4885SMN1; SMN2 4722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.