SCHEMBL28879162

SCHEMBL28879162

FC(F)(F)c1ccc(-c2cc(Cl)nc(-c3ccc(C(F)(F)F)cc3)n2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.52
S1PR1 P21453 1/20 0.48
S1PR3 Q99500 1/20 0.48
KDM4E B2RXH2 2/20 0.45
ALDH1A1 P00352 1/20 0.45
HSD17B10 Q99714 1/20 0.45
TOP1 P11387 2/20 0.44
RAD51 Q06609 1/20 0.43
CASP1 P29466 1/20 0.43
KIF11 P52732 2/20 0.42
CASP3 P42574 2/20 0.42
ALOX5 P09917 1/20 0.41
CTSS P25774 1/20 0.41
CTSK P43235 1/20 0.41
DPP4 P27487 2/20 0.41
LMNA P02545 3/20 0.40
THRB P10828 1/20 0.40
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
NPC1 O15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7228785 0.94 KIF11 (0.52) ADORA3S1PR1S1PR3KDM4EALDH1A1
SCHEMBL5217538 0.91 S1PR1 (0.51) ADORA3S1PR1S1PR3KIF11CASP3
SCHEMBL4619849 0.86 ALDH1A1 (0.46) ADORA3S1PR1S1PR3KDM4EALDH1A1
SCHEMBL25459772 0.84 S1PR1 (0.53) S1PR1KDM4EALDH1A1TOP1KIF11
SCHEMBL30085885 0.84 S1PR1 (0.53) S1PR1KDM4EALDH1A1TOP1KIF11
SCHEMBL2848055 0.84 RAD51 (0.48) ADORA3S1PR1S1PR3KDM4EALDH1A1
SCHEMBL4716132 0.83 RAD51 (0.48) ADORA3S1PR1S1PR3KDM4EALDH1A1
SCHEMBL1643582 0.83 KDM4E (0.62) KDM4EALDH1A1HSD17B10TOP1CASP1
SCHEMBL29894012 0.83 S1PR1 (0.46) ADORA3S1PR1S1PR3KDM4EALDH1A1
SCHEMBL8031410 0.83 LMNA (0.62) ADORA3S1PR1S1PR3RAD51KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110407816-A A kind of compound and application and device using the compound UNIV TSINGHUA 2019-11-05 CN disclosed