Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ESRRG | P62508 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744480 | 0.85 | SIRT6 (0.60) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL3482783 | 0.80 | ALDH1A1 (0.60) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL28335402 | 0.80 | MAPT (0.51) | MAPTALDH1A1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL1126955 | 0.79 | MAPT (0.57) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL374834 | 0.79 | SIRT6 (0.68) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL11668124 | 0.78 | DRD2 (0.49) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1045279 | 0.78 | SIRT6 (0.62) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL2730000 | 0.77 | KDM4E (0.63) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL7760522 | 0.77 | SIRT6 (0.54) | SIRT6MAPTALDH1A1LMNAPOLB | |
| SCHEMBL6945690 | 0.77 | SIRT6 (0.65) | SIRT6MAPTALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551105-B | Substituted triazoles useful as AXL inhibitors | 里格尔制药公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-110551105-A | substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2019-12-10 | — | — | CN | disclosed |