SCHEMBL28882452

SCHEMBL28882452

CNc1ccc(O[Si](C)(C)C(C)(C)C)c(O[Si](C)(C)C(C)(C)C)c1

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.34
CA12 O43570 4/20 0.33
CA1 P00915 4/20 0.33
CA9 Q16790 4/20 0.33
EGFR P00533 2/20 0.31
IMPDH2 P12268 1/20 0.30
IMPDH1 P20839 1/20 0.30
PIM1 P11309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4763704 0.77 EGFR (0.33) CA12CA1CA9EGFR
SCHEMBL17362169 0.76 PREP (0.44) CA12CA1CA9
SCHEMBL9687650 0.76 NPSR1 (0.42) DRD2IMPDH2IMPDH1
SCHEMBL13705723 0.74 CA1 (0.43) DRD2CA12CA1CA9
SCHEMBL9687075 0.74 ALDH1A1 (0.37) DRD2CA12CA1CA9IMPDH2
SCHEMBL30148554 0.74 DRD2 (0.38) DRD2
SCHEMBL31706038 0.74 NPSR1 (0.39) EGFR
SCHEMBL31444192 0.74 CA12 (0.42) CA12CA1CA9
SCHEMBL22323741 0.73 DRD2 (0.46) DRD2CA12CA1CA9
SCHEMBL22801149 0.72 EDNRB (0.35) DRD2CA12CA1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110621654-B TRPV1 modulator compounds 安塔尔遗传学公司 2022-11-01 CN disclosed
CN-110621654-A TRPV1 modulator compounds 安塔尔遗传学公司 2019-12-27 CN disclosed