Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889168 | 0.89 | CTSA (0.43) | CTSASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL28889346 | 0.87 | CTSA (0.42) | CTSASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL29941884 | 0.85 | SMARCA2 (0.38) | CTSAL3MBTL1POLB | |
| SCHEMBL28889319 | 0.84 | ADRB2 (0.41) | SMN1; SMN2MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL28889243 | 0.84 | OPRM1 (0.36) | CTSAOPRM1OPRL1L3MBTL1 | |
| SCHEMBL28889227 | 0.80 | CTSA (0.47) | CTSASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL29941704 | 0.78 | ADRB2 (0.39) | CTSAMEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL28889388 | 0.75 | ALDH1A1 (0.36) | CTSASMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL28889187 | 0.74 | MEN1 (0.40) | CTSARAB9AMEN1MAPTKMT2A | |
| SCHEMBL29941823 | 0.74 | ADRB2 (0.40) | SMN1; SMN2MEN1MAPTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |