Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 4/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889260 | 0.82 | SMARCA2 (0.38) | CTSAOPRM1OPRL1SMN1; SMN2CXCL8 | |
| SCHEMBL28889221 | 0.81 | ADRB2 (0.41) | OPRL1MEN1MAPTHPGDKMT2A | |
| SCHEMBL28889189 | 0.80 | CTSA (0.45) | CTSAOPRM1OPRL1NPC1RAB9A | |
| SCHEMBL28889272 | 0.80 | OPRL1 (0.38) | OPRM1OPRL1 | |
| SCHEMBL28889168 | 0.78 | CTSA (0.43) | CTSAOPRM1OPRL1NPC1RAB9A | |
| SCHEMBL28889346 | 0.77 | CTSA (0.42) | CTSAOPRM1OPRL1NPC1RAB9A | |
| SCHEMBL28889276 | 0.72 | ALDH1A1 (0.54) | CTSAOPRM1OPRL1NPC1RAB9A | |
| SCHEMBL19716970 | 0.71 | PLAU (0.43) | NPC1RAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL28889339 | 0.71 | ADRB2 (0.42) | CTSA | |
| SCHEMBL29718864 | 0.70 | ACP3 (0.50) | MEN1KMT2ACXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |