Water

Water

SCHEMBL28889229

O.O=C=Nc1ccc(N=C=O)cc1.O=C=Nc1ccc(N=C=O)cc1

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.67
TSHR P16473 1/20 0.67
TDP1 Q9NUW8 2/20 0.54
MAPK1 P28482 1/20 0.54
TRPA1 O75762 1/20 0.50
CYP1A2 P05177 1/20 0.45
GABRA1 P14867 1/20 0.37
GABRB2 P47870 1/20 0.37
P2RY6 Q15077 1/20 0.35
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
MIF P14174 1/20 0.33
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
EPHX2 P34913 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15430 0.97 CYP3A4 (0.70) CYP3A4TSHRTDP1MAPK1TRPA1
SCHEMBL27741428 0.93 CYP3A4 (0.67) CYP3A4TSHRTDP1MAPK1TRPA1
Ammonia Solution, Strong SCHEMBL28239770 0.93 CYP3A4 (0.67) CYP3A4TSHRTDP1MAPK1TRPA1
Water SCHEMBL3898007 0.91 CYP3A4 (0.58) CYP3A4TSHRTDP1MAPK1TRPA1
Cyclohexane SCHEMBL1006843 0.88 CYP3A4 (0.61) CYP3A4TSHRTDP1MAPK1TRPA1
SCHEMBL28301007 0.88 CYP3A4 (0.61) CYP3A4TSHRTDP1MAPK1TRPA1
SCHEMBL241534 0.88 CYP3A4 (0.61) CYP3A4TSHRTDP1MAPK1TRPA1
SCHEMBL333218 0.88 CYP3A4 (0.61) CYP3A4TSHRTDP1MAPK1TRPA1
SCHEMBL333217 0.88 CYP3A4 (0.61) CYP3A4TSHRTDP1MAPK1TRPA1
Hydrogen Sulfide SCHEMBL3894665 0.85 CYP3A4 (0.58) CYP3A4TSHRTDP1MAPK1TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111183131-B Method for recovering organic amine 旭化成株式会社 2022-06-28 CN disclosed
CN-107963982-B Polyisocyanate composition and isocyanate polymer composition 旭化成株式会社 2021-11-12 CN disclosed
CN-111183131-A Method for recovering organic amine 旭化成株式会社 2020-05-19 CN disclosed