Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CTSA | P10619 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889243 | 0.90 | OPRM1 (0.36) | IDO1OPRM1OPRL1BRD4ROCK2 | |
| SCHEMBL28889296 | 0.88 | HDAC4 (0.40) | ALDH1A1DHODHMEN1KMT2A | |
| SCHEMBL28889168 | 0.84 | CTSA (0.43) | OPRM1OPRL1ALDH1A1CTSAMEN1 | |
| SCHEMBL28889388 | 0.82 | ALDH1A1 (0.36) | BRD4ALDH1A1CTSAMEN1KMT2A | |
| SCHEMBL29941823 | 0.81 | ADRB2 (0.40) | IDO1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL28889192 | 0.80 | HDAC4 (0.39) | DHODHMEN1KMT2A | |
| SCHEMBL28889272 | 0.80 | OPRL1 (0.38) | IDO1OPRM1OPRL1DHODH | |
| SCHEMBL29941833 | 0.78 | HDAC4 (0.41) | DHODHMEN1KMT2ALMNA | |
| SCHEMBL28889346 | 0.74 | CTSA (0.42) | OPRM1OPRL1ALDH1A1CTSAMEN1 | |
| SCHEMBL28889189 | 0.73 | CTSA (0.45) | OPRM1OPRL1ALDH1A1CTSAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |