Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 8/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | NEK4 | P51957 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889238 | 0.91 | ADRB2 (0.37) | P2RY1ADRB2LMNAPOLBCYP3A4 | |
| SCHEMBL29893632 | 0.91 | ADRB2 (0.37) | P2RY1ADRB2LMNAPOLBCYP3A4 | |
| SCHEMBL28889349 | 0.90 | P2RY1 (0.41) | P2RY1ADRB2LMNAPOLBCYP3A4 | |
| SCHEMBL29942209 | 0.87 | ADRB2 (0.38) | P2RY1ADRB2KCNN4LMNAPOLB | |
| SCHEMBL29941794 | 0.84 | ADRB2 (0.38) | ADRB2KCNN4LMNAPOLBALDH1A1 | |
| SCHEMBL29942331 | 0.84 | ADRB2 (0.38) | P2RY1ADRB2KCNN4LMNAPOLB | |
| SCHEMBL29941803 | 0.84 | HDAC4 (0.42) | P2RY1ADRB2LMNAPOLBALDH1A1 | |
| SCHEMBL29941823 | 0.83 | ADRB2 (0.40) | ADRB2LMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL28889381 | 0.81 | ADRB2 (0.39) | P2RY1ADRB2KCNN4ALDH1A1L3MBTL1 | |
| SCHEMBL28889196 | 0.81 | TACR1 (0.43) | ADRB2LMNAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |