Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889357 | 0.88 | ALDH1A1 (0.39) | LMNAPHGDHALDH1A1GRIN1GRIN2B | |
| SCHEMBL29941818 | 0.87 | HDAC4 (0.41) | LMNAPHGDHHDAC4HDAC7HDAC5 | |
| SCHEMBL28889342 | 0.85 | OPRM1 (0.40) | LMNAPHGDHHDAC4HDAC7HDAC5 | |
| SCHEMBL28889315 | 0.85 | PHGDH (0.39) | LMNAPHGDHALDH1A1CRHR1 | |
| SCHEMBL28889259 | 0.85 | HDAC4 (0.42) | HDAC4HDAC7HDAC5KMT2ANPSR1 | |
| SCHEMBL28889177 | 0.83 | HDAC4 (0.40) | LMNAPHGDHHDAC4HDAC7HDAC5 | |
| SCHEMBL29893652 | 0.83 | PDE4B (0.38) | LMNAPHGDHALDH1A1CRHR1PDE4B | |
| SCHEMBL28889234 | 0.83 | PDE4B (0.38) | LMNAPHGDHALDH1A1CRHR1PDE4B | |
| SCHEMBL28889330 | 0.83 | ALDH1A1 (0.44) | LMNAPHGDHALDH1A1CRHR1IDH1 | |
| SCHEMBL28889214 | 0.82 | HDAC4 (0.39) | PHGDHHDAC4HDAC7HDAC5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |