Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PHGDH | O43175 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889315 | 0.89 | PHGDH (0.39) | ALDH1A1LMNAPHGDHGAAADRB2 | |
| SCHEMBL28889290 | 0.88 | LMNA (0.40) | ALDH1A1LMNAPHGDHKMT2APDE4B | |
| SCHEMBL28889177 | 0.83 | HDAC4 (0.40) | ALDH1A1LMNAPHGDHGAAHTT | |
| SCHEMBL29893652 | 0.82 | PDE4B (0.38) | ALDH1A1LMNAPHGDHGAAHTT | |
| SCHEMBL28889234 | 0.82 | PDE4B (0.38) | ALDH1A1LMNAPHGDHGAAHTT | |
| SCHEMBL28889330 | 0.80 | ALDH1A1 (0.44) | ALDH1A1LMNAPHGDHGAAADRB2 | |
| SCHEMBL28889338 | 0.80 | LMNA (0.41) | LMNAPHGDHHTTKMT2AMEN1 | |
| SCHEMBL28889248 | 0.79 | LMNA (0.41) | ALDH1A1LMNAPHGDHHTTKMT2A | |
| SCHEMBL29893626 | 0.79 | LMNA (0.41) | ALDH1A1LMNAPHGDHHTTKMT2A | |
| SCHEMBL28889273 | 0.76 | ADRB2 (0.40) | ALDH1A1GAAADRB2KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |