Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29942056 | 0.91 | ALDH1A1 (0.43) | OPRM1OPRL1HDAC5HDAC4HDAC7 | |
| SCHEMBL28889233 | 0.90 | PHGDH (0.41) | ADRB2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL29941818 | 0.90 | HDAC4 (0.41) | OPRM1OPRL1HDAC5HDAC4HDAC7 | |
| SCHEMBL28889259 | 0.86 | HDAC4 (0.42) | OPRM1OPRL1HDAC5HDAC4HDAC7 | |
| SCHEMBL28889290 | 0.85 | LMNA (0.40) | OPRL1HDAC5HDAC4HDAC7KMT2A | |
| SCHEMBL28889214 | 0.84 | HDAC4 (0.39) | OPRM1OPRL1HDAC5HDAC4HDAC7 | |
| SCHEMBL28889250 | 0.84 | MEN1 (0.44) | OPRM1OPRL1HDAC5HDAC4HDAC7 | |
| SCHEMBL29893755 | 0.84 | MEN1 (0.44) | OPRM1OPRL1HDAC5HDAC4HDAC7 | |
| SCHEMBL29941667 | 0.82 | OPRM1 (0.44) | OPRM1OPRL1HDAC5HDAC4HDAC7 | |
| SCHEMBL28889200 | 0.82 | ADRB2 (0.41) | ADRB2MEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |