Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 10/20 | 0.39 |
| ▸ | BUB1 | O43683 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889690 | 0.89 | NPSR1 (0.55) | CYP1A2CYP3A4CYP2D6CYP2C9PMP22 | |
| SCHEMBL5318243 | 0.84 | CCR2 (0.36) | BUB1PDE5APOLB | |
| SCHEMBL2889225 | 0.83 | CYP2D6 (0.44) | CYP1A2CYP3A4CYP2D6CYP2C9PMP22 | |
| SCHEMBL2880797 | 0.79 | PDE5A (0.52) | CYP1A2CYP3A4CYP2D6CYP2C9PMP22 | |
| SCHEMBL27800001 | 0.74 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2D6CYP2C9PMP22 | |
| SCHEMBL927783 | 0.74 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C9PMP22 | |
| SCHEMBL29562255 | 0.73 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2D6CYP2C9PMP22 | |
| SCHEMBL1603062 | 0.73 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2D6CYP2C9PMP22 | |
| SCHEMBL5320369 | 0.73 | NR1H2 (0.43) | PDE5A | |
| SCHEMBL1603498 | 0.72 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113507-A1 | 3-Tetrazolyl Indazoles, 3-Tetrazolyl Pyrazolopyridines, and use Thereof | BAYER HEALTHCARE AG (DE) | 2010-05-06 | — | — | US | claimed |
| US-20100113507-A1 | 3-Tetrazolyl Indazoles, 3-Tetrazolyl Pyrazolopyridines, and use Thereof | BAYER HEALTHCARE AG (DE) | 2010-05-06 | — | — | US | disclosed |
| EP-2024361-A1 | 3-TETRAZOLYL INDAZOLES, 3-TETRAZOLYL PYRAZOLOPYRIDINES, AND USE THEREOF | Bayer HealthCare AG (DE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007128454-A1 | 3-TETRAZOLYL INDAZOLES, 3-TETRAZOLYL PYRAZOLOPYRIDINES, AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113507-A1 | 3-Tetrazolyl Indazoles, 3-Tetrazolyl Pyrazolopyridines, and use Thereof | TNNI3, FABP3, PPIP5K2 | CYP1A2 328/4885CYP3A4 129/4885CYP2D6 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.