Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.34 |
| ▸ | F13A1 | P00488 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | TGM1 | P22735 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16137967 | 0.87 | MAPT (0.41) | SYKATRMAPTEGLN2CA12 | |
| SCHEMBL28895279 | 0.82 | CA12 (0.41) | SYKATRMAPTEGLN2CA12 | |
| SCHEMBL793197 | 0.81 | ATR (0.42) | SYKATRMAPTEGLN2CA12 | |
| SCHEMBL28895114 | 0.78 | ENPP2 (0.36) | SYKATRMAPTEGLN2CA12 | |
| SCHEMBL19511536 | 0.77 | ATR (0.44) | ATRCA12CA1CA9NAMPT | |
| SCHEMBL17629762 | 0.77 | RARA (0.43) | SYKEGLN2CA12CA1CA9 | |
| SCHEMBL28895294 | 0.77 | RORC (0.35) | SYKATRMAPTEGLN2CA12 | |
| SCHEMBL17643122 | 0.76 | CA12 (0.39) | SYKEGLN2CA12CA1CA9 | |
| SCHEMBL28895142 | 0.75 | CA12 (0.41) | SYKEGLN2F13A1TGM2TGM1 | |
| SCHEMBL15076456 | 0.75 | CA12 (0.42) | SYKEGLN2CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315805-A | Aromatic ring-fused cyclic lactone thiohydantoin compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-04-12 | — | — | CN | disclosed |