Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propiophenone SCHEMBL28271870 | 0.85 | L3MBTL1 (0.60) | MAPTL3MBTL1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL301100 | 0.85 | GSK3B (0.64) | MAPTL3MBTL1SMN1; SMN2LMNAGSK3B | |
| Ethylene SCHEMBL11738819 | 0.81 | GSK3B (0.59) | MAPTL3MBTL1SMN1; SMN2LMNAGSK3B | |
| SCHEMBL8987897 | 0.80 | SMN1; SMN2 (0.68) | MAPTL3MBTL1SMN1; SMN2LMNAGSK3B | |
| Ethyl 4-Pyridylketone SCHEMBL805505 | 0.77 | PLOD2 (0.57) | MAPTL3MBTL1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL11780135 | 0.77 | GSK3B (0.57) | MAPTL3MBTL1SMN1; SMN2GSK3BHDAC3 | |
| Pyridine SCHEMBL22721371 | 0.77 | LMNA (0.55) | MAPTL3MBTL1SMN1; SMN2LMNAKDM4E | |
| Pyridine SCHEMBL27704354 | 0.77 | LMNA (0.55) | MAPTSMN1; SMN2LMNAKDM4EGSK3B | |
| SCHEMBL6142684 | 0.75 | SRD5A2 (0.53) | MAPTL3MBTL1SMN1; SMN2LMNAGSK3B | |
| SCHEMBL9342342 | 0.75 | GSK3B (0.52) | MAPTL3MBTL1SMN1; SMN2LMNAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269227-A | Process for preparing 1,2, 3-trisubstituted indolizine derivatives | 淮阴师范学院 | 2020-06-12 | — | — | CN | disclosed |