Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPBWR1 | P48145 | 7/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GRK2 | P25098 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863497 | 0.85 | TDP1 (0.51) | MEN1KMT2ACNR2KAT2B | |
| SCHEMBL20401101 | 0.83 | GLS (0.57) | MAPTSMN1; SMN2NPBWR1MEN1KMT2A | |
| SCHEMBL28899162 | 0.82 | NPBWR1 (0.56) | NPBWR1AURKAGRK2ROCK1RPS6KA1 | |
| SCHEMBL5864274 | 0.79 | PDE5A (0.43) | MAPTSMN1; SMN2MEN1KMT2AKAT2B | |
| SCHEMBL9874375 | 0.78 | GLS (0.50) | MAPTMEN1KMT2AKAT2B | |
| SCHEMBL30579886 | 0.78 | TDP1 (0.64) | NPBWR1MCHR1 | |
| SCHEMBL30879415 | 0.77 | DCTPP1 (0.45) | MAPTSMN1; SMN2NPBWR1MCHR1MEN1 | |
| SCHEMBL22226011 | 0.75 | NPBWR1 (0.62) | MAPTNPBWR1AURKAGRK2ROCK1 | |
| SCHEMBL1163283 | 0.75 | CNR2 (0.56) | MAPTSMN1; SMN2CNR2 | |
| SCHEMBL25432622 | 0.74 | NPBWR1 (0.55) | NPBWR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456308-B | Heterocyclic compounds as ASK inhibitors and their use | 南京圣和药业股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-109456308-A | Heterocyclic compound and its application as ASK inhibitor | 南京圣和药业股份有限公司 | 2019-03-12 | — | — | CN | disclosed |