SCHEMBL28902304

SCHEMBL28902304

O=C(O)c1ccc2[nH]cc(Cc3c[nH]c4cc([N+](=O)[O-])ccc34)c2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPRA P18433 1/20 0.58
PKM P14618 1/20 0.57
PKLR P30613 1/20 0.57
CYP2C19 P33261 1/20 0.56
HTR7 P34969 1/20 0.53
NQO2 P16083 1/20 0.51
MAPT P10636 3/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
GPR84 Q9NQS5 1/20 0.48
CDK2 P24941 2/20 0.47
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
GAA P10253 1/20 0.46
TDP1 Q9NUW8 1/20 0.43
GABRP O00591 1/20 0.43
GABRD O14764 1/20 0.43
GABRA1 P14867 1/20 0.43
GABRB1 P18505 1/20 0.43
GABRG2 P18507 1/20 0.43
GABRB3 P28472 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28902340 0.89 PKM (0.56) PTPRAPKMPKLRCYP2C19NQO2
SCHEMBL10921361 0.85 PLA2G4A (0.56) PTPRAPKMPKLRCYP2C19NQO2
SCHEMBL8425209 0.84 NQO2 (0.55) PTPRAPKMPKLRCYP2C19HTR7
SCHEMBL5424833 0.83 HTR7 (0.72) CYP2C19HTR7MAPTGPR84MEN1
SCHEMBL6719869 0.82 PLA2G4A (0.58) PTPRAHTR7NQO2MAPTSMN1; SMN2
SCHEMBL29660260 0.82 PLA2G4A (0.58) PTPRAHTR7NQO2MAPTSMN1; SMN2
SCHEMBL27929617 0.82 NQO2 (0.61) PTPRAPKMPKLRCYP2C19NQO2
SCHEMBL6716658 0.82 PLA2G4A (0.58) PTPRAHTR7NQO2MAPTSMN1; SMN2
SCHEMBL30029554 0.81 GPR84 (0.64) PTPRAPKMPKLRCYP2C19NQO2
SCHEMBL28902316 0.81 GPR84 (0.64) PTPRAPKMPKLRCYP2C19NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115403501-B Preparation method and application of 3,3' -diaryl methane compound 五邑大学 2024-03-26 CN disclosed
CN-115403501-A Preparation method and application of 3,3' -diarylmethane compound 五邑大学 2022-11-29 CN disclosed