Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.47 |
| ▸ | STS | P08842 | 7/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28909557 | 1.00 | TGFBR1 (0.47) | TGFBR1STSGPR119KDM4EPKM | |
| SCHEMBL28521125 | 0.86 | HRH1 (0.38) | PKMCCR8 | |
| SCHEMBL20135307 | 0.84 | MMP13 (0.56) | STSGPR119MMP13MMP1 | |
| SCHEMBL20135306 | 0.84 | MMP13 (0.56) | STSGPR119MMP13MMP1 | |
| SCHEMBL28364155 | 0.78 | ALDH1A1 (0.46) | TGFBR1STSGPR119KDM4E | |
| SCHEMBL28831408 | 0.76 | NR1H2 (0.41) | TGFBR1STSGPR119KDM4EPKM | |
| SCHEMBL29139941 | 0.74 | GPR119 (0.42) | TGFBR1STSGPR119 | |
| SCHEMBL24362392 | 0.73 | MMP13 (0.48) | STSGPR119KDM4EMMP13MMP1 | |
| SCHEMBL2538106 | 0.73 | GPR119 (0.50) | TGFBR1STSGPR119KDM4EPKM | |
| SCHEMBL2538102 | 0.73 | GPR119 (0.50) | TGFBR1STSGPR119KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |