Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367640 | 0.83 | AKT1 (0.58) | AKT1MAPTMAPK1TDP1KMT2A | |
| SCHEMBL8189830 | 0.81 | AKT1 (0.56) | AKT1MAPTMAPK1TDP1KMT2A | |
| SCHEMBL28264973 | 0.78 | MAPK1 (0.56) | AKT1MAPTMAPK1TDP1KMT2A | |
| SCHEMBL11070858 | 0.78 | TDP1 (0.61) | AKT1MAPTMAPK1TDP1KMT2A | |
| Benzophenone SCHEMBL18171700 | 0.78 | ALDH1A1 (0.56) | AKT1MAPTMAPK1TDP1KMT2A | |
| SCHEMBL305090 | 0.76 | MAPK1 (0.58) | AKT1MAPTMAPK1TDP1KMT2A | |
| SCHEMBL8755824 | 0.75 | HPGD (0.64) | AKT1MAPTMAPK1TDP1KMT2A | |
| Oxirane SCHEMBL27647497 | 0.75 | AKT1 (0.48) | AKT1MAPTMAPK1TDP1KMT2A | |
| SCHEMBL6304856 | 0.74 | MAPK1 (0.56) | AKT1MAPTMAPK1TDP1KMT2A | |
| SCHEMBL10414732 | 0.74 | MAPK1 (0.56) | AKT1MAPTMAPK1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753446-B2 | Beta-hairpin peptidomimetics | POLYPHOR AG (CH) | 2023-09-12 | — | — | US | disclosed |
| EP-4214220-A1 | ANTIMICROBIAL PEPTIDOMIMETICS | Spexis AG (CH) | 2023-07-26 | — | — | EP | disclosed |
| EP-4214221-A1 | ANTIMICROBIAL PEPTIDOMIMETICS | Spexis AG (CH) | 2023-07-26 | — | — | EP | disclosed |
| EP-3087094-B1 | BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS | POLYPHOR AG (CH) | 2022-06-01 | — | — | EP | disclosed |
| EP-3201218-B1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2021-11-03 | — | — | EP | disclosed |
| EP-3087087-B1 | BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS | POLYPHOR AG (CH) | 2021-07-21 | — | — | EP | disclosed |
| US-20200231629-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2020-07-23 | — | — | US | disclosed |
| US-10370412-B2 | Beta-hairpin peptidomimetics | POLYPHOR AG (CH) | 2019-08-06 | — | — | US | disclosed |
| EP-2978771-B1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2019-07-24 | — | — | EP | disclosed |
| EP-2427476-B1 | BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY | POLYPHOR AG (CH) | 2018-08-08 | — | — | EP | disclosed |
| US-8716242-B2 | β-hairpin peptidomimetics | POLYPHOR AG (CH) | 2014-05-06 | — | — | US | disclosed |
| EP-2540736-A2 | Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity | Polyphor AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| US-20120283168-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY | POLYPHOR AG (CH) | 2012-11-08 | — | — | US | disclosed |
| EP-2427476-A1 | BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY | Polyphor Ag (CH) | 2012-03-14 | — | — | EP | disclosed |
| EP-1879911-B1 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS | POLYPHOR LTD (CH) | 2011-08-17 | — | — | EP | disclosed |
| US-20110135576-A1 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS | POLYPHOR LTD. (CH) | 2011-06-09 | — | — | US | disclosed |
| WO-2010127704-A1 | BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY | POLYPHOR AG (CH) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010060479-A1 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY | POLYPHOR AG (CH) | 2010-06-03 | — | — | WO | disclosed |
| EP-1689863-A1 | TEMPLATE FIXED BETA-HAIRPIN LOOP MIMETICS AND THEIR USE IN PHAGE DISPLAY | Polyphor Ltd. (CH) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005047503-A1 | TEMPLATE FIXED ΒΕΤΑ-HAIRPIN LOOP MIMETICS AND THEIR USE IN PHAGE DISPLAY | POLYPHOR LTD. (CH) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200231629-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | BET1, BACH1, POLL | AKT1 2845/4885MAPT 2072/4885MAPK1 2575/4885 |
| US-20120283168-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY | CCR10, CCR1, CCRL2 | AKT1 4389/4885MAPT 3273/4885MAPK1 1997/4885 |
| US-20110135576-A1 | DYE CONJUGATES OF TEMPLATE-FIXED PEPTIDOMIMETICS | CXCR4, CXCL12, CXCR1 | AKT1 870/4885MAPT 3179/4885MAPK1 3275/4885 |
| US-10370412-B2 | Beta-hairpin peptidomimetics | POLL, BACE1, C1S | AKT1 1789/4885MAPT 1457/4885MAPK1 1501/4885 |
| US-11753446-B2 | Beta-hairpin peptidomimetics | POLL, BACE1, C1S | AKT1 1929/4885MAPT 2235/4885MAPK1 1908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.