Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 10/20 | 0.54 |
| ▸ | PKLR | P30613 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28919028 | 0.91 | PKM (0.51) | HTTPKMPKLRPOLBKMT2A | |
| SCHEMBL28919157 | 0.87 | POLB (0.58) | HTTPOLBKMT2AALDH1A1NPSR1 | |
| SCHEMBL28961516 | 0.87 | ALDH1A1 (0.66) | HTTPKMPKLRPOLBALDH1A1 | |
| SCHEMBL29043226 | 0.78 | KMT2A (0.56) | HTTPOLBKMT2AALDH1A1TDP1 | |
| SCHEMBL28919063 | 0.75 | PKM (0.55) | PKMPKLRPOLBKMT2A | |
| SCHEMBL12346544 | 0.75 | PKM (0.68) | PKMPKLRKMT2AALDH1A1LMNA | |
| SCHEMBL28919048 | 0.74 | ALDH1A1 (0.67) | HTTPOLBKMT2AALDH1A1NPSR1 | |
| SCHEMBL546627 | 0.74 | HTT (0.77) | HTTPOLBALDH1A1NPSR1TDP1 | |
| SCHEMBL12346543 | 0.74 | PKM (0.73) | HTTPKMPKLRPOLBKMT2A | |
| SCHEMBL2239830 | 0.73 | PKM (1.00) | PKMPKLRPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115521272-B | Benzenesulfonyl piperazine compound and medical application thereof | 河北省人民医院 | 2023-07-21 | — | — | CN | disclosed |
| CN-115521272-A | Benzenesulfonyl piperazine compound and medical application thereof | 河北省人民医院 | 2022-12-27 | — | — | CN | disclosed |