Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 6/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28660399 | 0.90 | ALDH1A1 (0.39) | ALK | |
| SCHEMBL28654896 | 0.89 | BRD4 (0.45) | IKBKETBK1TNIKABL1 | |
| SCHEMBL28663832 | 0.86 | INSR (0.46) | CHEK1INSRALKLRRK2IKBKE | |
| SCHEMBL28929167 | 0.81 | EGFR (0.40) | INSRALKTYK2TNIKKCNH2 | |
| SCHEMBL28660407 | 0.75 | BRD4 (0.52) | IKBKETBK1TNIK | |
| SCHEMBL28929166 | 0.74 | — | — | |
| SCHEMBL28672733 | 0.70 | MAPT (0.51) | CHEK1LRRK2IKBKETBK1IGF1R | |
| SCHEMBL25769210 | 0.68 | CHEK1 (0.53) | CHEK1IKBKETBK1IGF1RMAPK10 | |
| SCHEMBL28053893 | 0.66 | ALK (0.63) | CHEK1INSRALKLRRK2TBK1 | |
| SCHEMBL28663835 | 0.66 | KDM4E (0.42) | INSRALKLRRK2TNIKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113717158-A | 2- (N- (pyridine-2-yl) amino) quinoline derivative and application thereof | 河南省人民医院 | 2021-11-30 | — | — | CN | claimed |
| CN-113717158-A | 2- (N- (pyridine-2-yl) amino) quinoline derivative and application thereof | 河南省人民医院 | 2021-11-30 | — | — | CN | disclosed |