SCHEMBL289387

SCHEMBL289387

CCc1cc(C(O)(C(F)(F)F)C(F)(F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(C#N)c(N)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNJ11 Q14654 5/20 0.36
ABCC9 O60706 3/20 0.36
ABCC8 Q09428 3/20 0.36
KCNJ8 Q15842 3/20 0.36
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPT P10636 3/20 0.34
HPGD P15428 2/20 0.34
ALOX15 P16050 1/20 0.34
HSD17B10 Q99714 1/20 0.34
AR P10275 3/20 0.33
LCK P06239 2/20 0.33
POLB P06746 1/20 0.33
MLYCD O95822 1/20 0.32
KDR P35968 1/20 0.32
TEK Q02763 1/20 0.32
MAPK1 P28482 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
KIT P10721 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3217239 0.90 KDM4E (0.35) KDM4EALDH1A1MAPTHPGDALOX15
SCHEMBL3709143 0.85 MAPT (0.43) KCNJ11ABCC9ABCC8KCNJ8ALDH1A1
SCHEMBL3220253 0.84 KDM4E (0.40) KCNJ11ABCC9ABCC8KCNJ8KDM4E
SCHEMBL3226663 0.83 ALDH1A1 (0.42) KCNJ11ABCC9ABCC8KCNJ8KDM4E
SCHEMBL3709719 0.83 ABCC9 (0.37) KCNJ11ABCC9ABCC8KCNJ8ALDH1A1
SCHEMBL3701195 0.81 LCK (0.39) KCNJ11ABCC9ABCC8KCNJ8MAPT
SCHEMBL3224891 0.81 HDAC1 (0.35) KDM4EALDH1A1HPGDHSD17B10LCK
SCHEMBL1420650 0.81 S1PR3 (0.40) KDM4EALDH1A1MAPTHPGDALOX15
SCHEMBL3213487 0.80 KDM4E (0.34) KCNJ11ABCC9ABCC8KCNJ8KDM4E
SCHEMBL1275497 0.80 MLYCD (0.51) KCNJ11ABCC9ABCC8KCNJ8KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106242998-B Use of 4-cyano-3-benzoylamino-N-phenyl-benzamides in pesticides 先正达参股股份有限公司 2021-11-05 CN disclosed
EP-2427427-B1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2013-12-25 EP disclosed
WO-2013092942-A1 USE OF AMINOBENZAMIDE DERIVATIVES FOR CONTROLLING ANIMAL PARASITES SYNGENTA PARTICIPATIONS AG (CH) 2013-06-27 WO disclosed
US-8431514-B2 4-cyano-3-benzoylamino-N-phenyl-benzamides for use in pest control SYNGENTA CROP PROTECTION LLC (US) 2013-04-30 US disclosed
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA CROP PROTECTION LLC (US) 2012-05-17 US disclosed
EP-2427427-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL Syngenta Participations AG (CH) 2012-03-14 EP disclosed
WO-2010127926-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL NISCH, AADAC, ACHE KCNJ11 1568/4885ABCC9 274/4885ABCC8 1041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.