SCHEMBL2895207

SCHEMBL2895207

Clc1ccc(Oc2cc[c]cn2)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HAO1 Q9UJM8 2/20 0.47
KMO O15229 2/20 0.46
HSP90AA1 P07900 1/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
KDM4E B2RXH2 1/20 0.40
POLB P06746 1/20 0.40
HTR2A P28223 11/20 0.38
SLC6A4 P31645 11/20 0.38
KCNH2 Q12809 10/20 0.38
HRH3 Q9Y5N1 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2901814 0.81 L3MBTL1 (0.44) HAO1MEN1KMT2AKDM4EHRH3
SCHEMBL2894981 0.79 KMT2A (0.36) MEN1KMT2AKDM4E
SCHEMBL693084 0.79 CYP1A2 (0.50) HTR2ASLC6A4KCNH2HRH3
SCHEMBL2897588 0.77 HAO1 (0.47) HAO1MEN1KMT2AKDM4E
SCHEMBL19211769 0.77 CHRNA3 (0.36)
SCHEMBL2750901 0.77 MAP4K4 (0.43) MEN1KMT2AKDM4EHTR2ASLC6A4
SCHEMBL2901099 0.75 LMNA (0.41) MEN1KMT2AHTR2ASLC6A4KCNH2
SCHEMBL693602 0.74 HSP90AA1 (0.55) HAO1KMOHSP90AA1MEN1KMT2A
SCHEMBL2752841 0.74 CA2 (0.47) MEN1KMT2AKDM4E
SCHEMBL1712271 0.74 MEN1 (0.50) MEN1KMT2AKDM4EHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100305124-A1 Acylated Aminopyridine and Aminopyridazine Insecticides BAYER CROPSCIENCE AG (DE) 2010-12-02 US disclosed
EP-2236505-A1 Acylated aminopyridines and pyridazines as insecticides Bayer CropScience AG (DE) 2010-10-06 EP disclosed
US-4954497-A AGRICULTURE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-09-04 US disclosed
EP-0330939-A2 Acrylic acid morpholides, their production and use Takeda Chemical Industries, Ltd. (JP) 1989-09-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100305124-A1 Acylated Aminopyridine and Aminopyridazine Insecticides AAAS, DDT, QDPR HAO1 3072/4885KMO 1047/4885HSP90AA1 3740/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.