Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 8/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | BCL9 | O00512 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25920180 | 0.82 | PRKAG1 (0.41) | DDB1CRBNHSD11B1MEN1KMT2A | |
| SCHEMBL31232873 | 0.81 | CRBN (0.52) | DDB1CRBNSIGMAR1HPGDL3MBTL3 | |
| SCHEMBL25240043 | 0.81 | CRBN (0.49) | DDB1CRBN | |
| SCHEMBL30158164 | 0.81 | CRBN (0.49) | DDB1CRBN | |
| SCHEMBL31678103 | 0.80 | DDB1 (0.53) | DDB1CRBNSIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL31630953 | 0.77 | CRBN (0.46) | DDB1CRBNSIGMAR1 | |
| SCHEMBL24778021 | 0.76 | GABRD (0.48) | L3MBTL3L3MBTL1 | |
| SCHEMBL24778022 | 0.75 | NR3C1 (0.41) | HSD11B1MEN1KMT2ABCL9CTNNB1 | |
| SCHEMBL31236426 | 0.74 | DDB1 (0.62) | DDB1CRBNHPGDPARP1 | |
| SCHEMBL25249148 | 0.74 | CRBN (0.42) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4393922-A1 | IRAK4 DEGRADATION AGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Leadingtac Pharmaceutical Co. Ltd. (CN) | 2024-07-03 | — | — | EP | disclosed |
| CN-115710274-A | IRAK4 degradation agent, preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2023-02-24 | — | — | CN | disclosed |