SCHEMBL289804 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	CTSC	P53634	8/20	0.42

▸	KCNH2	Q12809	1/20	0.35

▸	LTB4R	Q15722	1/20	0.35

▸	LTB4R2	Q9NPC1	1/20	0.35

▸	CTSL	P07711	8/20	0.34

▸	CTSS	P25774	6/20	0.34

▸	CTSB	P07858	5/20	0.34

▸	CTSK	P43235	6/20	0.33

▸	MAPK1	P28482	3/20	0.33

▸	AR	P10275	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL288986	0.86	MMP1 (0.41)	CTSCKCNH2LTB4RLTB4R2CTSL
SCHEMBL2891840	0.83	CTSC (0.56)	CTSCKCNH2LTB4RLTB4R2CTSK
SCHEMBL290024	0.82	CTSC (0.49)	CTSCKCNH2LTB4RLTB4R2CTSL
SCHEMBL290266	0.82	CTSC (0.38)	CTSCKCNH2LTB4RLTB4R2CTSL
SCHEMBL290154	0.82	FFAR1 (0.40)	CTSCKCNH2LTB4RLTB4R2CTSL
SCHEMBL290666	0.81	CTSC (0.38)	CTSCKCNH2LTB4RLTB4R2CTSL
SCHEMBL290312	0.81	CTSC (0.41)	CTSCKCNH2LTB4RLTB4R2CTSL
SCHEMBL290246	0.80	ALDH1A1 (0.41)	CTSCCTSLCTSSCTSBCTSK
SCHEMBL289883	0.79	CTSL (0.37)	CTSCKCNH2LTB4RLTB4R2CTSL
SCHEMBL290110	0.79	CTSC (0.56)	CTSCCTSLCTSSCTSBCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2427445-A1	SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750	AstraZeneca AB (SE)	2012-03-14	—	—	EP	disclosed
WO-2010128324-A1	SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750	ASTRAZENECA AB (SE)	2010-11-11	—	—	WO	disclosed