Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluorene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 4/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorene SCHEMBL27831385 | 0.94 | TDP1 (0.44) | ALDH1A1GLATDP1MEN1KMT2A | |
| Fluorene SCHEMBL919560 | 0.94 | TDP1 (0.44) | ALDH1A1GLATDP1MEN1KMT2A | |
| Fluorene SCHEMBL3914798 | 0.93 | ALDH1A1 (0.45) | ALDH1A1GLATDP1MEN1KMT2A | |
| Fluorene SCHEMBL28675258 | 0.86 | ALDH1A1 (0.40) | ALDH1A1TDP1MGLL | |
| Fluorene SCHEMBL154228 | 0.85 | TDP1 (0.47) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL3407086 | 0.84 | ALDH1A1 (0.45) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL27912741 | 0.84 | TDP1 (0.50) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL28404082 | 0.84 | TDP1 (0.50) | ALDH1A1GLATDP1MEN1KMT2A | |
| 2-Phenylphenol SCHEMBL28050949 | 0.84 | ALDH1A1 (0.46) | ALDH1A1GLATDP1MGLL | |
| Alcohol SCHEMBL28004110 | 0.83 | PNMT (0.38) | ALDH1A1GLATDP1MGLLNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116158208-A | Polarizing plate, polarizing plate with retardation layer, and image display device comprising the polarizing plate or polarizing plate with retardation layer | 日东电工株式会社 | 2023-05-23 | — | — | CN | disclosed |
| CN-115997144-A | Polarizing plate, polarizing plate with retardation layer, and image display device | 日东电工株式会社 | 2023-04-21 | — | — | CN | disclosed |