Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 8/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16167356 | 0.85 | CYP3A4 (0.51) | CYP3A4LMNAACHEMTNR1AMTNR1B | |
| SCHEMBL16167355 | 0.84 | ACHE (0.53) | CYP3A4LMNAACHEMTNR1AMTNR1B | |
| SCHEMBL13314605 | 0.81 | ALDH1A1 (0.55) | CYP3A4LMNAACHEMTNR1AMTNR1B | |
| SCHEMBL21225979 | 0.80 | ALOX5 (0.57) | CYP3A4LMNAACHEMTNR1AMTNR1B | |
| SCHEMBL715536 | 0.80 | CYP3A4 (0.56) | CYP3A4LMNAACHEPARP1CNR2 | |
| SCHEMBL1561685 | 0.80 | CYP3A4 (0.56) | CYP3A4LMNAACHEMTNR1AMTNR1B | |
| SCHEMBL9005287 | 0.80 | TAAR1 (0.59) | MTNR1AMTNR1BGPR52HDAC1HDAC6 | |
| SCHEMBL9005286 | 0.80 | TAAR1 (0.59) | MTNR1AMTNR1BGPR52HDAC1HDAC6 | |
| SCHEMBL21811074 | 0.78 | CYP3A4 (0.54) | CYP3A4LMNAACHEMTNR1AMTNR1B | |
| SCHEMBL715236 | 0.78 | LMNA (0.54) | CYP3A4LMNAACHEMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632452-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | ProMetic BioSciences Inc. (CA) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012097427-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | PROMETIC BIOSCIENCES INC. (CA) | 2012-07-26 | — | — | WO | disclosed |
| EP-2427416-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | ProMetic BioSciences Inc. (CA) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127440-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | PROMETIC BIOSCIENCES INC. (CA) | 2010-11-11 | — | — | WO | disclosed |