SCHEMBL28997296

SCHEMBL28997296

N#CCC1CCC(=O)N1c1ccc(F)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 1/20 0.41
TDP1 Q9NUW8 1/20 0.39
ALDH1A1 P00352 2/20 0.38
PTGER3 P43115 2/20 0.38
PTGER2 P43116 2/20 0.38
KDM4E B2RXH2 2/20 0.37
MAPT P10636 2/20 0.37
MEN1 O00255 1/20 0.37
GAA P10253 1/20 0.37
KMT2A Q03164 1/20 0.37
CNR2 P34972 1/20 0.35
MGLL Q99685 1/20 0.35
PTGDR Q13258 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
KCNA5 P22460 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
P2RX7 Q99572 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28997274 0.85 AR (0.38) TDP1ALDH1A1PTGER3PTGER2KDM4E
SCHEMBL28997292 0.85 PTGER2 (0.40) ALDH1A1PTGER3PTGER2MEN1GAA
SCHEMBL28997141 0.85 RAB9A (0.38) ALDH1A1PTGER3PTGER2MEN1KMT2A
SCHEMBL28997140 0.85 PTGER2 (0.39) ALDH1A1PTGER3PTGER2KDM4EMAPT
SCHEMBL30226089 0.83 FAAH (0.41) ALDH1A1MAPTMEN1GAAKMT2A
SCHEMBL28997149 0.83 FAAH (0.41) ALDH1A1MAPTMEN1GAAKMT2A
SCHEMBL28997150 0.81 KMT2A (0.41) ALDH1A1MAPTMEN1GAAKMT2A
SCHEMBL16422721 0.80 HDAC1 (0.49) HTR7TDP1PTGER3PTGER2CNR2
SCHEMBL9893023 0.80 PER2 (0.46) HTR7TDP1ALDH1A1PTGER3PTGER2
SCHEMBL16422287 0.80 TDP1 (0.44) HTR7TDP1PTGER3PTGER2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115894323-A Method for self-cyclizing cyanation of enaminoaniline compound 湖北工业大学 2023-04-04 CN disclosed