Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119345 | 0.84 | GPR119 (0.44) | GPR119MEN1KMT2AMMP13 | |
| SCHEMBL3128149 | 0.84 | ALDH1A1 (0.51) | GPR119MEN1KMT2AKDM4EMMP13 | |
| SCHEMBL282240 | 0.84 | GPR119 (0.60) | GPR119MEN1KMT2AMMP13 | |
| SCHEMBL30965535 | 0.83 | MEN1 (0.38) | GPR119MEN1KMT2ARAB9AMMP13 | |
| SCHEMBL3119446 | 0.83 | KMT2A (0.48) | GPR119MEN1KMT2AMMP13 | |
| SCHEMBL3120252 | 0.83 | KMT2A (0.48) | GPR119MEN1KMT2AMMP13 | |
| SCHEMBL3119461 | 0.83 | KMT2A (0.48) | GPR119MEN1KMT2AMMP13 | |
| SCHEMBL28410550 | 0.83 | DRD2 (0.47) | KMT2AALDH1A1ACACB | |
| SCHEMBL3116724 | 0.82 | GPR119 (0.42) | GPR119MEN1KMT2AMMP13 | |
| SCHEMBL30981046 | 0.82 | MMP13 (0.44) | GPR119MEN1KMT2ARAB9AMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116322700-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-23 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |