Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 6/20 | 0.43 |
| ▸ | TPSD1 | Q9BZJ3 | 6/20 | 0.43 |
| ▸ | TPSG1 | Q9NRR2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29260116 | 0.90 | TPSAB1 (0.39) | TPSAB1TPSD1TPSG1ALDH1A1NPC1 | |
| SCHEMBL29260114 | 0.90 | TPSAB1 (0.39) | TPSAB1TPSD1TPSG1ALDH1A1NPC1 | |
| SCHEMBL29179866 | 0.86 | ALDH1A1 (0.55) | TPSAB1TPSD1TPSG1ALDH1A1NPC1 | |
| SCHEMBL29260222 | 0.85 | TPSAB1 (0.44) | TPSAB1TPSD1TPSG1ALDH1A1NPC1 | |
| SCHEMBL29144075 | 0.81 | TPSAB1 (0.44) | TPSAB1TPSD1TPSG1ALDH1A1NPC1 | |
| SCHEMBL27668729 | 0.81 | TPSAB1 (0.41) | TPSAB1TPSD1TPSG1ALDH1A1NPC1 | |
| SCHEMBL29143913 | 0.81 | POLB (0.46) | TPSAB1TPSD1TPSG1ALDH1A1NPC1 | |
| SCHEMBL28857052 | 0.81 | ALDH1A1 (0.49) | TPSAB1TPSD1TPSG1ALDH1A1F2 | |
| SCHEMBL28425908 | 0.79 | EPHX2 (0.45) | TPSAB1TPSD1TPSG1ALDH1A1NPC1 | |
| SCHEMBL25024582 | 0.77 | GNAI3 (0.57) | ALDH1A1NPC1KMT2AGNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076607-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-117794936-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-03-29 | — | — | CN | disclosed |
| CN-116322700-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-23 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |