Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 5/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906434 | 0.76 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL1260378 | 0.74 | CNR1 (0.49) | HSD11B1 | |
| SCHEMBL2903583 | 0.73 | RXFP1 (0.47) | HSD11B1 | |
| SCHEMBL2907793 | 0.71 | CNR1 (0.48) | — | |
| SCHEMBL3111631 | 0.70 | CNR1 (0.56) | HSD11B1 | |
| SCHEMBL2570109 | 0.69 | ESR1 (0.51) | HSD11B1 | |
| SCHEMBL4083519 | 0.68 | NSD2 (0.56) | HSD11B1DPP4DPP8OPRL1 | |
| SCHEMBL2543644 | 0.67 | CNR1 (0.46) | DPP4 | |
| SCHEMBL1258893 | 0.66 | MARS1 (0.52) | — | |
| SCHEMBL2933108 | 0.66 | AHR (0.67) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899298-B1 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2010-08-18 | — | — | EP | disclosed |