Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | RHOC | P08134 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929394 | 0.82 | LMNA (0.49) | CNR1CNR2MAPTMEN1KMT2A | |
| SCHEMBL3113355 | 0.75 | PPARD (0.47) | CNR1CNR2PPARDEPHX2NR1H4 | |
| SCHEMBL2840701 | 0.74 | CNR1 (0.45) | CNR1CNR2PPARDEPHX2NR1H4 | |
| SCHEMBL3107295 | 0.74 | CNR1 (0.47) | CNR1CNR2PPARDEPHX2NR1H4 | |
| SCHEMBL3110196 | 0.72 | DPP4 (0.48) | CNR1CNR2PPARDEPHX2NR1H4 | |
| SCHEMBL2901352 | 0.71 | HSD11B1 (0.48) | — | |
| SCHEMBL3111640 | 0.70 | CNR1 (0.44) | CNR1CNR2PPARDEPHX2NR1H4 | |
| SCHEMBL3113188 | 0.69 | PPARD (0.44) | CNR1CNR2PPARDEPHX2NR1H4 | |
| SCHEMBL20477571 | 0.69 | MEN1 (0.73) | EPHX2MEN1CYP1A2CYP2C19KMT2A | |
| SCHEMBL2903583 | 0.69 | RXFP1 (0.47) | MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899298-B1 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2010-08-18 | — | — | EP | disclosed |
| US-7618995-B2 | Derivatives of 4,5-diarylpyrrole, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2009-11-17 | — | — | US | disclosed |
| US-20080176924-A1 | antiinflammatory agents; cannabinoid receptor modulators; obesity; antagonists; N-((5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-methyl-1H-pyrrol-2-yl)methyl)-4-(trifluoromethyl)benzamide | SANOFI-AVENTIS (FR) | 2008-07-24 | — | — | US | disclosed |
| EP-1899298-A2 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007000505-A2 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176924-A1 | antiinflammatory agents; cannabinoid receptor modulators; obesity; antagonists; N-((5-(4-chlorophenyl)-4-(2,4-dichlorophenyl)-1-methyl-1H-pyrrol-2-yl)methyl)-4-(trifluoromethyl)benzamide | CNR1, CNR2, GPR119 | CNR1 1/4885CNR2 2/4885PPARD 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.