Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2901352 | 0.73 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL4490242 | 0.72 | ALDH1A1 (0.42) | HSD11B1ALDH1A1PKMKDM4ECYP19A1 | |
| SCHEMBL1380439 | 0.71 | OPRL1 (0.62) | — | |
| SCHEMBL4490618 | 0.70 | OPRL1 (0.57) | HSD11B1ALDH1A1PKMHTR6CYP19A1 | |
| SCHEMBL4505757 | 0.70 | PGR (0.48) | ALDH1A1PKMKDM4ELMNACYP19A1 | |
| SCHEMBL12919530 | 0.69 | RXFP1 (0.46) | RXFP1ALDH1A1LMNACYP19A1KMT2A | |
| SCHEMBL2929394 | 0.69 | LMNA (0.49) | ALDH1A1LMNACCR1KDRKMT2A | |
| SCHEMBL908983 | 0.69 | OPRL1 (0.47) | — | |
| SCHEMBL2907793 | 0.69 | CNR1 (0.48) | LMNAKMT2AMEN1 | |
| SCHEMBL1377778 | 0.68 | OPRL1 (0.53) | ALDH1A1PKMHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899298-B1 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2010-08-18 | — | — | EP | disclosed |
| EP-1899298-A2 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007000505-A2 | DERIVATIVES OF 4,5-DIARYLPYRROLE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2007-01-04 | — | — | WO | disclosed |