Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 3/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288985 | 0.89 | MMP1 (0.41) | CD274CTSCCTSKMMP2MMP3 | |
| SCHEMBL290037 | 0.87 | RET (0.36) | CD274CTSCCTSKTP53MMP2 | |
| SCHEMBL290023 | 0.87 | CTSC (0.45) | CD274CTSCMMP13MMP1KCNH2 | |
| SCHEMBL290245 | 0.85 | CTSS (0.39) | CTSKMMP13MMP1 | |
| SCHEMBL289882 | 0.84 | CTSC (0.32) | CTSCKCNH2LTB4RLTB4R2HIF1A | |
| SCHEMBL289589 | 0.83 | RORC (0.37) | CTSCMMP2MMP3MMP9MMP8 | |
| SCHEMBL290311 | 0.82 | MMP12 (0.44) | CTSCMMP13KCNH2LTB4RLTB4R2 | |
| SCHEMBL290665 | 0.82 | CTSC (0.34) | CTSCCTSKKCNH2LTB4RLTB4R2 | |
| SCHEMBL290265 | 0.82 | CTSC (0.34) | CTSCCTSKKCNH2LTB4RLTB4R2 | |
| SCHEMBL299846 | 0.81 | MMP1 (0.35) | CTSCMMP2MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427445-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | AstraZeneca AB (SE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128324-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | WO | disclosed |