Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28647910 | 0.76 | PARP1 (0.43) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL2720401 | 0.75 | CA1 (0.37) | RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL29021133 | 0.74 | F11 (0.33) | — | |
| SCHEMBL28658382 | 0.71 | TPMT (0.33) | — | |
| SCHEMBL28438507 | 0.71 | CES2 (0.34) | — | |
| SCHEMBL28647199 | 0.70 | HCAR3 (0.38) | — | |
| SCHEMBL28715604 | 0.69 | S1PR2 (0.35) | — | |
| SCHEMBL3813595 | 0.69 | ALDH1A1 (0.36) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL28487595 | 0.69 | ALDH1A1 (0.46) | MAPTHPGD | |
| SCHEMBL24269886 | 0.69 | OPRM1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117624131-A | 3- [ (1H-pyrazol-4-yl) oxy ] pyrazin-2-amine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117624130-A | 3- [ (1H-pyrazol-4-yl) oxy ] pyrazin-2-amine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-116323565-A | 3- [ (1H-pyrazol-4-yl) oxy ] pyrazin-2-amine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2023-06-23 | — | — | CN | disclosed |