SCHEMBL29024489

SCHEMBL29024489

CC(C)COc1ccc(Cn2nc(CC3CC3)cc2C2CCNCC2)cc1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 0.39
HTR2A P28223 10/20 0.38
SLC16A3 O15427 5/20 0.38
SLC16A1 P53985 5/20 0.38
MCTS1 Q9ULC4 2/20 0.38
MAP3K12 Q12852 1/20 0.34
GPR4 P46093 1/20 0.33
PRMT5 O14744 1/20 0.33
WDR77 Q9BQA1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29024481 0.88 HTR2A (0.42) ABL1HTR2A
SCHEMBL29024639 0.87 SLC16A3 (0.41) ABL1HTR2ASLC16A3SLC16A1MCTS1
SCHEMBL29024488 0.83 ABL1 (0.39) ABL1HTR2ASLC16A3SLC16A1MCTS1
SCHEMBL30478109 0.79 LTA4H (0.36) SLC16A3SLC16A1MCTS1
SCHEMBL30478119 0.76 SLC16A3 (0.38) SLC16A3SLC16A1MCTS1
SCHEMBL29024642 0.75 HTR2A (0.41) HTR2A
SCHEMBL29024487 0.74 HRH1 (0.40) ABL1HTR2ASLC16A3SLC16A1MCTS1
SCHEMBL29024647 0.74 HTR2A (0.51) HTR2A
SCHEMBL5764465 0.72 CCR5 (0.46) GPR4
Hydrochloric Acid SCHEMBL5765862 0.71 CCR5 (0.46) GPR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116354925-A Pyrazole derivatives and use thereof 江苏恩华药业股份有限公司 2023-06-30 CN claimed
CN-116354925-A Pyrazole derivatives and use thereof 江苏恩华药业股份有限公司 2023-06-30 CN disclosed