Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18280697 | 0.83 | EPHX1 (0.44) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL9950972 | 0.83 | EPHX1 (0.46) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL5981079 | 0.80 | TRPM8 (0.48) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL112084 | 0.78 | EPHX1 (0.47) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL30846576 | 0.78 | TRPM8 (0.46) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL19809105 | 0.77 | TRPM8 (0.44) | EPHX1TRPM8TRPA1TRPV1CYP19A1 | |
| SCHEMBL1032282 | 0.76 | EPHX1 (0.49) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL9951821 | 0.76 | EPHX1 (0.49) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL29018734 | 0.74 | EPHX1 (0.47) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL30904661 | 0.73 | TRPM8 (0.48) | EPHX1TRPM8TRPA1TRPV1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119604269-A | Composition for enhancing cooling effect | 弗门尼舍公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-118414086-A | Antimicrobial compositions with encapsulated colorants | 弗门尼舍有限公司 | 2024-07-30 | — | — | CN | disclosed |
| CN-117715614-A | Quick-drying perfume composition | 弗门尼舍有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-117693332-A | Oral care compositions | 弗门尼舍有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117479843-A | Composition for enhancing cooling effect | 弗门尼舍公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-116744889-A | Composition for enhancing cooling effect | 弗门尼舍公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-116568267-A | Compositions comprising (bio) -alkanediol and cooling agent | 西姆莱斯股份公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-115988967-A | Composition for reducing peroxide odor and application thereof | 弗门尼舍有限公司 | 2023-04-18 | — | — | CN | disclosed |