Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950972 | 0.84 | EPHX1 (0.46) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| Bicarbonate SCHEMBL29029158 | 0.83 | EPHX1 (0.45) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL112084 | 0.80 | EPHX1 (0.47) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL5981079 | 0.79 | TRPM8 (0.48) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL19809105 | 0.78 | TRPM8 (0.44) | EPHX1TRPM8TRPA1TRPV1CYP19A1 | |
| SCHEMBL1032282 | 0.78 | EPHX1 (0.49) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL9951821 | 0.78 | EPHX1 (0.49) | EPHX1TRPM8TRPA1TRPV1KCNA5 | |
| SCHEMBL5336220 | 0.77 | EPHX1 (0.42) | EPHX1TRPM8TRPA1TRPV1CYP19A1 | |
| SCHEMBL30846576 | 0.76 | TRPM8 (0.46) | EPHX1TRPM8TRPA1TRPV1 | |
| SCHEMBL29018734 | 0.76 | EPHX1 (0.47) | EPHX1TRPM8TRPA1TRPV1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3817575-B1 | SOLUBILISATION OF COOLING AGENTS OF LOW SOLUBILITY | SYMRISE AG (DE) | 2025-10-15 | — | — | EP | claimed |
| EP-3303281-B1 | PHYSIOLOGICAL COOLING COMPOUNDS | SYMRISE INC (US) | 2021-12-29 | — | — | EP | claimed |
| EP-3817575-A1 | SOLUBILIZATION OF POORLY SOLUBLE COOLING SUBSTANCES | Symrise AG (DE) | 2021-05-12 | — | — | EP | claimed |
| CN-112384077-A | Solubilization of poorly soluble cooling substances | 西姆莱斯有限公司 | 2021-02-19 | — | — | CN | claimed |
| WO-2020007484-A1 | SOLUBILIZATION OF POORLY SOLUBLE COOLING SUBSTANCES | SYMRISE AG (DE) | 2020-01-09 | — | — | WO | claimed |
| US-10173966-B2 | Physiological cooling compounds | SYMRISE, INC. (US) | 2019-01-08 | — | — | US | claimed |
| US-20180179147-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | SYMRISE, INC. | 2018-06-28 | — | — | US | claimed |
| EP-3303281-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | Symrise, Inc. (US) | 2018-04-11 | — | — | EP | claimed |
| US-20160355463-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | SYMRISE, INC. | 2016-12-08 | — | — | US | claimed |
| WO-2016196751-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | PINOVA HOLDINGS, INC. (US) | 2016-12-08 | — | — | WO | claimed |
| EP-3817575-B1 | SOLUBILISATION OF COOLING AGENTS OF LOW SOLUBILITY | SYMRISE AG (DE) | 2025-10-15 | — | — | EP | disclosed |
| EP-3817575-A1 | SOLUBILIZATION OF POORLY SOLUBLE COOLING SUBSTANCES | Symrise AG (DE) | 2021-05-12 | — | — | EP | disclosed |
| US-10981862-B2 | Physiological cooling compounds | SYMRISE, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| CN-112384077-A | Solubilization of poorly soluble cooling substances | 西姆莱斯有限公司 | 2021-02-19 | — | — | CN | disclosed |
| WO-2020007484-A1 | SOLUBILIZATION OF POORLY SOLUBLE COOLING SUBSTANCES | SYMRISE AG (DE) | 2020-01-09 | — | — | WO | disclosed |
| US-10173966-B2 | Physiological cooling compounds | SYMRISE, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180179147-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | SYMRISE, INC. | 2018-06-28 | — | — | US | disclosed |
| EP-3303281-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | Symrise, Inc. (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016196751-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | PINOVA HOLDINGS, INC. (US) | 2016-12-08 | — | — | WO | disclosed |
| US-20160355463-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | SYMRISE, INC. | 2016-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10981862-B2 | Physiological cooling compounds | TAS2R8, TAS2R3, TAS2R1 | EPHX1 2251/4885TRPM8 29/4885TRPA1 31/4885 |
| US-10173966-B2 | Physiological cooling compounds | TAS2R8, TAS2R3, TAS2R1 | EPHX1 2251/4885TRPM8 29/4885TRPA1 31/4885 |
| US-20160355463-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | TAS2R8, TAS2R3, TAS2R1 | EPHX1 2251/4885TRPM8 29/4885TRPA1 31/4885 |
| US-20180179147-A1 | PHYSIOLOGICAL COOLING COMPOUNDS | TAS2R8, TAS2R3, TAS2R1 | EPHX1 2251/4885TRPM8 29/4885TRPA1 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.