Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16028458 | 0.84 | LMNA (0.35) | DGAT1 | |
| SCHEMBL26829643 | 0.73 | TSHR (0.44) | — | |
| SCHEMBL21244722 | 0.72 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL16877059 | 0.70 | CYP2C19 (0.38) | DGAT1 | |
| SCHEMBL21244607 | 0.68 | LMNA (0.32) | — | |
| SCHEMBL23194516 | 0.68 | — | — | |
| SCHEMBL21245185 | 0.67 | ACLY (0.31) | DGAT1 | |
| SCHEMBL31124647 | 0.67 | CYP1A2 (0.40) | — | |
| SCHEMBL28499103 | 0.67 | SLC22A6 (0.46) | — | |
| SCHEMBL28017992 | 0.66 | EGLN1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285547-A | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-112004817-B | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-06-23 | — | — | CN | disclosed |