Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.31 |
| ▸ | APLNR | P35414 | 2/20 | 0.31 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30461153 | 1.00 | NR3C1 (0.31) | NR3C1APLNRMEP1BALDH1A1CYP2C19 | |
| SCHEMBL25171404 | 0.88 | DUT (0.30) | APLNRMEP1BALDH1A1CYP2C19LMNA | |
| SCHEMBL28977729 | 0.88 | DUT (0.30) | APLNRMEP1BALDH1A1CYP2C19LMNA | |
| SCHEMBL20583291 | 0.83 | POLB (0.32) | NR3C1MEP1BALDH1A1CYP2C19ALPL | |
| SCHEMBL20294715 | 0.80 | DUT (0.33) | — | |
| SCHEMBL15988245 | 0.77 | ALDH1A1 (0.40) | MEP1BALDH1A1CYP2C19LMNAMEN1 | |
| SCHEMBL29020955 | 0.77 | PLA2G2C (0.38) | — | |
| SCHEMBL9615904 | 0.76 | RORC (0.39) | NR3C1MEP1BALDH1A1CYP2C19LMNA | |
| SCHEMBL9724989 | 0.76 | RORC (0.39) | NR3C1MEP1BALDH1A1CYP2C19LMNA | |
| SCHEMBL20583465 | 0.75 | ATM (0.36) | NR3C1MEP1BALDH1A1CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111902417-B | Diaryl macrocyclic compound, pharmaceutical composition and application thereof | 北京普祺医药科技股份有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-111902417-A | Diaryl macrocycle compound, pharmaceutical composition and application thereof | 北京普祺医药科技有限公司 | 2020-11-06 | — | — | CN | disclosed |