Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TK1 | P04183 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29231947 | 0.79 | TACR1 (0.39) | ATML3MBTL1KMT2ALMNAALDH1A1 | |
| SCHEMBL10608062 | 0.76 | MEN1 (0.39) | L3MBTL1KMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL15988245 | 0.75 | ALDH1A1 (0.40) | ATML3MBTL1MAPTKMT2ALMNA | |
| SCHEMBL29043266 | 0.75 | NR3C1 (0.31) | ATML3MBTL1KMT2ALMNAMEN1 | |
| SCHEMBL30461153 | 0.75 | NR3C1 (0.31) | ATML3MBTL1KMT2ALMNAMEN1 | |
| SCHEMBL9615904 | 0.74 | RORC (0.39) | ATML3MBTL1MAPTKMT2ALMNA | |
| SCHEMBL9724989 | 0.74 | RORC (0.39) | ATML3MBTL1MAPTKMT2ALMNA | |
| SCHEMBL17666797 | 0.74 | KAT6A (0.37) | MAPTKMT2ALMNAMEN1 | |
| SCHEMBL20583291 | 0.73 | POLB (0.32) | ATML3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL9614144 | 0.73 | MEP1B (0.36) | ATML3MBTL1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370739-B2 | Sacubitril intermediate and preparation method thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-06-28 | — | — | US | disclosed |
| EP-3424899-B1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2022-05-11 | — | — | EP | disclosed |
| US-20200079721-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | NORTH & SOUTH BROTHER PHARMACY INVESTMENT COMPANY LIMITED (HK) | 2020-03-12 | — | — | US | disclosed |
| US-10479753-B2 | Sacubitril intermediate and preparation method thereof | SUNSHINE LAKE PHARMA CO., LTD (CN) | 2019-11-19 | — | — | US | disclosed |
| EP-3424899-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2019-01-09 | — | — | EP | disclosed |
| US-20180362439-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079721-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | DPP4, ACE, DPP8 | ATM 3110/4885L3MBTL1 3133/4885TK1 3036/4885 |
| US-20180362439-A1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | ACE, DPP4, SI | ATM 2245/4885L3MBTL1 2952/4885TK1 3504/4885 |
| US-11370739-B2 | Sacubitril intermediate and preparation method thereof | DPP4, ACE, DPP8 | ATM 3110/4885L3MBTL1 3133/4885TK1 3036/4885 |
| US-10479753-B2 | Sacubitril intermediate and preparation method thereof | ACE, DPP4, SI | ATM 2245/4885L3MBTL1 2952/4885TK1 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.