Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | DHODH | Q02127 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29044466 | 0.89 | MAPT (0.65) | MAPTNPC1HPGDRAB9ADHODH | |
| SCHEMBL29044465 | 0.86 | MAPT (0.50) | MAPTNPC1HPGDRAB9ADHODH | |
| SCHEMBL29044463 | 0.84 | MAPT (0.45) | MAPTNPC1HPGDRAB9ADHODH | |
| SCHEMBL29044485 | 0.84 | MAPT (0.57) | MAPTNPC1HPGDRAB9AKDM4E | |
| SCHEMBL29044490 | 0.83 | KDM4E (0.67) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL29044453 | 0.80 | LMNA (0.57) | MAPTNPC1HPGDRAB9ADHODH | |
| SCHEMBL29044452 | 0.75 | TP53 (0.70) | MAPTNPC1HPGDRAB9AKDM4E | |
| SCHEMBL29044443 | 0.73 | ALDH1A1 (0.43) | MAPTNPC1HPGDRAB9ADHODH | |
| SCHEMBL280460 | 0.72 | GAA (0.40) | MAPTNPC1HPGDRAB9ADHODH | |
| SCHEMBL1267026 | 0.72 | TRPM8 (0.48) | MAPTNPC1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116531373-A | Thiazole compound, pharmaceutical composition and application thereof | 上海日馨医药科技股份有限公司 | 2023-08-04 | — | — | CN | disclosed |