Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | MPI | P34949 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905367 | 0.90 | KDM4E (0.56) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL2899752 | 0.86 | ALDH1A1 (0.64) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL2905445 | 0.77 | KDM4E (0.64) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL2901489 | 0.77 | KDM4E (0.59) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL7011577 | 0.75 | KDM4E (0.97) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL2906516 | 0.75 | KDM4E (0.61) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL13050024 | 0.75 | KDM4E (0.69) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL17808944 | 0.74 | LMNA (0.56) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL19361114 | 0.73 | LMNA (0.58) | KDM4EALDH1A1GAALMNAGLA | |
| SCHEMBL3676964 | 0.73 | ALDH1A1 (0.58) | KDM4EALDH1A1GAALMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507674-B2 | Quorum sensing inhibitor | THE UNIVERSITY OF TOKYO (JP) | 2013-08-13 | — | — | US | disclosed |
| US-8507674-B2 | Quorum sensing inhibitor | THE UNIVERSITY OF TOKYO (JP) | 2013-08-13 | — | — | US | disclosed |
| US-8507674-B2 | Quorum sensing inhibitor | THE UNIVERSITY OF TOKYO (JP) | 2013-08-13 | — | — | US | disclosed |
| US-20100256369-A1 | QUORUM SENSING INHIBITOR | THE UNIVERSITY OF TOKYO (JP) | 2010-10-07 | — | — | US | disclosed |
| US-20100256369-A1 | QUORUM SENSING INHIBITOR | THE UNIVERSITY OF TOKYO (JP) | 2010-10-07 | — | — | US | disclosed |
| US-20100256369-A1 | QUORUM SENSING INHIBITOR | THE UNIVERSITY OF TOKYO (JP) | 2010-10-07 | — | — | US | disclosed |
| EP-2215910-A1 | QUORUM SENSING INHIBITOR | The University of Tokyo (JP) | 2010-08-11 | — | — | EP | disclosed |
| EP-2215910-A1 | QUORUM SENSING INHIBITOR | The University of Tokyo (JP) | 2010-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256369-A1 | QUORUM SENSING INHIBITOR | BLVRB, API5, Q6ZSR9 | KDM4E 497/4885ALDH1A1 2904/4885GAA 4383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.