Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Toluene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toluene SCHEMBL3670161 | 1.00 | LMNA (0.61) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL248686 | 0.97 | LMNA (0.65) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL11123126 | 0.97 | LMNA (0.65) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL5070324 | 0.94 | LMNA (0.61) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL28219186 | 0.94 | LMNA (0.61) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL6518753 | 0.94 | LMNA (0.61) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL3973760 | 0.94 | LMNA (0.61) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL28004549 | 0.94 | LMNA (0.61) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL7627695 | 0.94 | LMNA (0.61) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL27784842 | 0.94 | LMNA (0.61) | LMNATSHRALOX12ACHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106318145-B | A kind of polyester-type water-based emulsion, preparation method and applications | 中国乐凯集团有限公司 | 2019-02-01 | — | — | CN | claimed |
| CN-106318145-A | Polyester type water-borne emulsion, preparing method and application thereof | 中国乐凯集团有限公司 | 2017-01-11 | — | — | CN | claimed |
| CN-104151589-A | Method for preparing low-haze polyester film | SUZHOU XILIN OPTOELECTRONICS TECHNOLOGY INDUSTRY CO LTD | 2014-11-19 | — | — | CN | claimed |
| EP-4710913-A2 | METHOD AND APPARATUS FOR DYEING HAIR FIBRES USING RADIO FREQUENCY ELECTROMAGNETIC RADIATION | Jemella Limited (GB) | 2026-03-18 | — | — | EP | disclosed |
| EP-3727307-B1 | METHOD AND APPARATUS FOR DYEING HAIR FIBRES USING RADIO FREQUENCY ELECTROMAGNETIC RADIATION | JEMELLA LTD (GB) | 2026-01-28 | — | — | EP | disclosed |
| US-11872295-B2 | Method and apparatus for dyeing hair fibres using radio frequency electromagnetic radiation | JEMELLA LIMITED (GB) | 2024-01-16 | — | — | US | disclosed |
| CN-112778475-B | Phenolic resin for aqueous adhesive and preparation method thereof | ＫＣＣ公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-116410505-A | Printable substrate and coating composition for printing | 南亚塑胶工业股份有限公司 | 2023-07-11 | — | — | CN | disclosed |
| US-20230203333-A1 | PRINTABLE SUBSTRATE AND COATING COMPOSITION FOR PRINTING | NAN YA PLASTICS CORPORATION (TW) | 2023-06-29 | — | — | US | disclosed |
| US-20230181429-A1 | METHOD AND APPARATUS FOR DYEING HAIR FIBRES USING RADIO FREQUENCY ELECTROMAGNETIC RADIATION | JEMELLA LIMITED (GB) | 2023-06-15 | — | — | US | disclosed |
| CN-108424713-B | Surfactant for workpiece, preparation method and workpiece surface spraying type pretreatment method | 佛山科富科技有限公司 | 2020-07-28 | — | — | CN | disclosed |
| US-20090114237-A1 | AIR OXIDATION HAIR DYE APPLICATION SYSTEM AND METHOD FOR COLORING HAIR USING THE SAME | COMBE INCORPORATED (US) | 2009-05-07 | — | — | US | disclosed |
| WO-2009058700-A2 | AIR OXIDATION HAIR DYE APPLICATION SYSTEM AND METHOD FOR COLORING HAIR USING THE SAME | COMBE INTERNATIONAL LTD. (US) | 2009-05-07 | — | — | WO | disclosed |
| US-7476679-B2 | Octahydroisoquinoline compounds as opioid receptor modulators | RESEARCH TRIANGLE INSTITUTE (US) | 2009-01-13 | — | — | US | disclosed |
| EP-1906962-A2 | OCTAHYDROISOQUINOLINE COMPOUNDS AS OPIOID RECEPTOR MODULATORS | RESEARCH TRIANGLE INSTITUTE (US) | 2008-04-09 | — | — | EP | disclosed |
| CN-101134865-A | Aqueous coating liquid composition for optical polyester film | NANYA PLASTICS CORP (CN) | 2008-03-05 | — | — | CN | disclosed |
| US-20070027182-A1 | Octahydroisoquinoline compounds as opioid receptor modulators | RESEARCH TRIANGLE INSTITUTE (US) | 2007-02-01 | — | — | US | disclosed |
| WO-2007014263-A2 | OCTAHYDROISOQUINOLINE COMPOUNDS AS OPIOID RECEPTOR MODULATORS | RESEARCH TRIANGLE INSTITUTE (US) | 2007-02-01 | — | — | WO | disclosed |
| US-6638882-B1 | Coating glass fiber with resole resin binder composition including catalyst comprising salt formed from ammonia and arylsulfonic acid, heating and compressing to produce molded fiber glass composition having enhanced thermal stability | KNAUF FIBER GLASS GMBH | 2003-10-28 | — | — | US | disclosed |
| US-6555616-B1 | Binder of an aqueous solution of a resole resin, a catalyst of an ammonia salt of an aryl sulfonic acid , and binder modifiers; shorter cure rate | KNAUF FIBER GLASS GMBH | 2003-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230181429-A1 | METHOD AND APPARATUS FOR DYEING HAIR FIBRES USING RADIO FREQUENCY ELECTROMAGNETIC RADIATION | DNMT1, CUTA, RAD1 | LMNA 642/4885TSHR 2048/4885ALOX12 4692/4885 |
| US-11872295-B2 | Method and apparatus for dyeing hair fibres using radio frequency electromagnetic radiation | DNMT1, CUTA, RAD1 | LMNA 642/4885TSHR 2048/4885ALOX12 4692/4885 |
| US-20070027182-A1 | Octahydroisoquinoline compounds as opioid receptor modulators | OPRL1, OPRM1, OPRK1 | LMNA 4808/4885TSHR 403/4885ALOX12 1592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.