Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14142621 | 0.80 | ALDH1A1 (0.43) | MAPTALDH1A1GAATSHRTP53 | |
| SCHEMBL770158 | 0.80 | MAPT (0.43) | MAPTALDH1A1GAATSHRTP53 | |
| SCHEMBL148781 | 0.76 | ALDH1A1 (0.55) | MAPTALDH1A1GAATSHRTP53 | |
| SCHEMBL3763790 | 0.76 | MAPT (0.40) | MAPTALDH1A1GAATSHRTP53 | |
| SCHEMBL97296 | 0.76 | ALDH1A1 (0.45) | MAPTALDH1A1GAATSHRTP53 | |
| SCHEMBL1330188 | 0.76 | ALDH1A1 (0.40) | MAPTALDH1A1GAATSHRTP53 | |
| SCHEMBL9297384 | 0.76 | TSHR (0.35) | ALDH1A1TSHRLMNAMAPK1TDP1 | |
| Iodide SCHEMBL31276096 | 0.74 | ALDH1A1 (0.53) | MAPTALDH1A1GAATSHRTP53 | |
| SCHEMBL14565683 | 0.74 | MAPT (0.39) | MAPTALDH1A1GAATSHRTP53 | |
| SCHEMBL19810860 | 0.74 | CHEK1 (0.52) | MAPTALDH1A1GAATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1657239-B1 | Chromene compound | TOKUYAMA CORP (JP) | 2010-08-11 | — | — | EP | disclosed |
| EP-1655293-B1 | Chromene compound and articles comprising the same | TOKUYAMA CORP (JP) | 2010-03-31 | — | — | EP | disclosed |
| EP-1655294-B1 | Chromene compound and articles comprising the same | TOKUYAMA CORP (JP) | 2010-03-24 | — | — | EP | disclosed |
| EP-1184379-B1 | CHROMENE COMPOUND | TOKUYAMA CORP (JP) | 2009-11-18 | — | — | EP | disclosed |
| US-7521004-B2 | Chromene compound | TOKUYAMA CORPORATION (JP) | 2009-04-21 | — | — | US | disclosed |
| EP-1674460-B1 | CHROMENE COMPOUND | TOKUYAMA CORP (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-20070215844-A1 | Chromene Compound | TOKUYAMA CORPORATION (JP) | 2007-09-20 | — | — | US | disclosed |
| EP-1674460-A1 | CHROMENE COMPOUND | Tokuyama Corporation (JP) | 2006-06-28 | — | — | EP | disclosed |
| EP-1657239-A2 | Chromene compound | Tokuyama Corporation (JP) | 2006-05-17 | — | — | EP | disclosed |
| EP-1655293-A2 | Chromene compound | Tokuyama Corporation (JP) | 2006-05-10 | — | — | EP | disclosed |
| EP-1655294-A2 | Chromene compound | Tokuyama Corporation (JP) | 2006-05-10 | — | — | EP | disclosed |
| US-6723859-B2 | BASE STRUCTURE IS A CHROMENE(3,2-A)FLUORENE RING CONTAINING SPIRO-FUSED RINGS; PHOTOCHROMIC LENSES; LARGE FADING RATE, LESS COLOR WHEN DETERIORATED, AND EXCELLENT LIGHT RESISTANCE IN THE PHOTOCHROMIC PROPERTIES | TOKUYAMA CORPORATION (JP) | 2004-04-20 | — | — | US | disclosed |
| US-20040014995-A1 | Chromene compounds | KAWABATA YUICHIRO (JP) | 2004-01-22 | — | — | US | disclosed |
| US-20030096117-A1 | Chromene compound | TOKUYAMA CORPORATION (JP) | 2003-05-22 | — | — | US | disclosed |
| US-6469076-B1 | Chromene compounds | TOKUYAMA CORPORATION (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-1054010-B1 | Chromene compound | TOKUYAMA CORP (JP) | 2002-07-24 | — | — | EP | disclosed |
| EP-1184379-A1 | CHROMENE COMPOUND | TOKUYAMA CORPORATION (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-6340765-B1 | PHOTOCHROMIC DYES AND DEVELOPMENT | TOKUYAMA CORPORATION (JP) | 2002-01-22 | — | — | US | disclosed |
| EP-1116723-A1 | CHROMENE COMPOUNDS | TOKUYAMA CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| EP-1054010-A1 | Chromene compound | TOKUYAMA CORPORATION (JP) | 2000-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014995-A1 | Chromene compounds | SMARCE1, SMARCB1, SMARCA2 | MAPT 1285/4885ALDH1A1 2905/4885GAA 3387/4885 |
| US-20070215844-A1 | Chromene Compound | CRY2, TYR, CRY1 | MAPT 520/4885ALDH1A1 2110/4885GAA 4597/4885 |
| US-20030096117-A1 | Chromene compound | SMARCE1, SMARCD2, SMARCB1 | MAPT 1368/4885ALDH1A1 3101/4885GAA 3439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.